hello
1.Difficult to Predict Temperaments.
2.Hard to Predict Adult Size.
3.Potential for High Risk Deliveries.
4.Still a Strong Chance for Congenital Health Issues.
5.May Be More Expensive Than a Purebred.
Explanation
The major disadvantages are that crossbreds also have the weaknesses of the breeds from which they descend and heterosis in initial crosses declines with any backcrossing to parental breeds
hope this answer correct :)