Answer: c)the Native Americans forming an alliance with Spain
Step-by-step explanation:
The Colombian Exchange which is named after Christopher Columbus, refers to the general transfer or resources, ideas and diseases between between the New World, Africa, and European nations in the 15th and 16th centuries.
The Native Americans were viewed as inferior by the Spanish who would go on to massacre quite a lot of them to have easy access to their resources such as gold. They enslaved them and took their lands and became their government and instead of fostering a cooperative alliance, simply ruled over them and in many cases very harshly.