Answer:
During the times of the Indian Removal Act, and the famous "Trail of Tears", the president of the time: Andrew Jackson, ordered the removal of several Native Peoples from the Southeastern United States, to the designated indian area in Oklahoma.
The ideas was to make up room for White American Settlers.
During the force evacuation of the Native Peoples, many of them perished due to disease, malnoursihment, or fatigue. This is why the event came to be known as the "Trail of Tears":