Question

Which of the following are considered strong bases? That is, they are capable of doing E2 reactions. (choose all that apply) Hydroxide, OH- Ammonia, NH3 Water, H20 ОMethanol, Снзон Methoxide, CH30- Cyanide, CN- Amide, NH2- Which of the following are considered strong nucleophiles? That is, they are capable of doing SN2 reactions. (choose all that apply) Hydroxide Ammonia Water Methanol Methoxide Cyanide Amide Which of the following are good leaving groups? (choose all that apply) Bromide Chloride Hydroxide Water Ammonia Cyanide

Answer 1

Answer:Strong bases: OH-, CH3O-, CN-

Nucleophiles: OH-,CN-, NH2-

Leaving groups: Br-, Cl-, H2O,NH3

Explanation: Strong bases have a greater ability to abstract a proton in an elimination reaction. For instance, the OH- easily abstracts a proton to form water. Nucleophilicity is a kinetic property. It measures the rate at which a specie displaces a leaving group from an alkyl halide Good leaving groups are stable anions or neutral molecules. They are often conjugate bases of strong acids.

The hydroxide ion rarely, or almost never acts as a leaving group in SN2 reactions