Answer:
As their name implies, GPCRs interact with G proteins in the plasma membrane. When an external signaling molecule binds to a GPCR, it causes a conformational change in the GPCR. This change then triggers the interaction between the GPCR and a nearby G protein.
What happens to the membrane protein (gray) when it is activated by the signal molecules?
The membrane protein interacts with the nearby GPCR.