Question

Cystic fibrosis is an autosomal recessive disorder where a chloride ion membrane channel protein doesn't function properly. People with cystic fibrosis suffer from chronic lung infections that make breathing very difficult. They also suffer from other issues such as an inability to produce enough digestive enzymes due to problems with pancreas cells. Suppose that Chris and Shannon are both carrier of cystic fibrosis (carriers have the allele but do not exhibit the disorder). What is Chris' genotype for the cystic fibrosis gene

Answer 1

Answer: Typically, the genotype in those patients consists of at least one very mild mutation uncharacteristic for CF patients. These are predominantly missense or splice variants, belonging to classes IV or V producing variable amounts of functional CFTR protein at the apical membrane.