Question

What is the biggest difference when comparing a prokaryotic and a eukaryotic cell?

Answer 1

The biggest difference between the two are that eukaryotic cells have a membrane-bound nucleus and prokaryotic cells do not.

Answer 2

Well, the primary distinction between these two types of organisms is that eukaryotic cells have a membrane-bound nucleus and prokaryotic cells do not. ... Prokaryotes, on the other hand, have no membrane-bound organelles. Another important difference is the DNA structure.