Answer: When Wayne said this, he meant that, the key to our successes is not our skill, but also our mentality. If you say "I can't do this" you will be stuck in mindset where you will fail, regardless of your efforts. When you have convinced yourself you are unable to do this, you will be stuck with an obstacle in your path. Bod brown once said "Behind every successful man, there's a lot of unsuccessful years." This just goes to show, no matter what you do, you have a chance to fail, but it your choice to get back up and try again. If you get knocked down, you can lay on the ground lying in failure, or, you can get up and try again. Tell yourself you can do it, because, you can. A persons attitude is what effects how they succeed. The mentality is a key part in overcoming difficulties and issues. Confidence is key, which cannot be more true. If you believe you will fail, then you have given up, before you even have tried. The opportunities Wayne mentions, is what you make of it, not what others tell you they see, but what you see, and what you can turn it into.
Hope this helps ^^
remember, tell yourself you can accomplish it, and then just like that, you've done it.