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13. How does the protein p53 act as a negative regulator?
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13. How does the protein p53 act as a negative regulator?

User Big Money
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Answer:

The major negative regulator of p53 is the Mdm2 proto-oncogene. Mdm2 is transcriptionally induced by p53, thus p53 triggers its own destruction through a negative feedback loop. This feedback loop leads to oscillations in the expression of both proteins following DNA damage.

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User Joachim Rosskopf
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