The impact of the rivalry between Soviet Union and United States in the Cold War distorted internal politics and exacerbated or complicated regional conflicts. Indeed, the grafting of the USA/USSR competition over pre-existing Middle Eastern rivalries in several cases intensified them. At the same time, though, and in some cases, the Middle Eastern political élites themselves made use of the Cold War to pursue their own interests of hegemony, security or colonial emancipation. Following Khalidi (2009) in assuming that during the Cold War the level of penetration of the Soviet and American influence was proportional to the degree of the strategic importance of the region, I will first discuss the strategic and geopolitical features of the Middle East. Secondly, I will describe some significant historical events, in order to show how the Cold War logic affected the area and how it shaped the region’s political reality, both from a regional and a domestic point of view.