One of the negative effects of the Columbia's Exchange was the introduction of new diseases to the Americas. Prior to the arrival of European explorers, the indigenous peoples of the Americas had no immunity to many of the diseases that were common in Europe, such as smallpox, measles, and influenza. As a result, these diseases spread quickly through the Americas, killing millions of people and decimating many indigenous communities.
Another negative effect of the Columbia's Exchange was the exploitation and enslavement of the indigenous peoples of the Americas. European explorers and settlers brought with them new technologies and weapons, which they used to enslave and exploit the indigenous peoples they encountered. This led to the forced labor and murder of many indigenous people, and contributed to the destruction of their cultures and way of life.
Overall, the Columbia's Exchange was a negative historical event due to the introduction of new diseases, the exploitation and enslavement of indigenous peoples, and the destruction of their cultures.
(You can use the conclusion if you want to.)