Question

A self-aldol or crossed aldol reaction REQUIRES a(n) ___________________. Group of answer choices strong acid only a very, very strong base, such as LDA (lithium diisopropyl amide), NaOH or LiOH won't work acid catalyst a strong base such as LiOH or NaOH

Answer 1

`\mathbf{a \ strong \ base \ such \ as\ LiOH \ or \ NaOH.}`

Step-by-step explanation:

In the condensation reactions of carbonyl compounds, it is essential to establish the order of events in advance to minimize or suppress the possibilities of self-condensation and the occurrence of cross-condensation, which unfortunately are an obvious threat in these reactions.

Self-condensation:

Any carbonyl compound that has one or more alpha hydrogens, on the carbons adjacent to the carbonyl group, runs the risk of undergoing a self-condensation reaction if the corresponding rigor is not carried out.

Cross-condensation:

Ideally, in the condensation reactions of carbonyl compounds, one of the reacting molecules should quickly enolise, while the other preferably should not have Hα, to ensure that no other by-products are formed.

`\text{To achieve this process;}`
`\text{A self-aldol or crossed aldol requires a strong base such as LiOH or NaOH.}`