Question

D) During Transcription, a nucleotide has been deleted. Explain the effect this will have

on DNA as well as what happens in each step along the way to a protein.

Answer 1

this mutation may change the open reading frame of the resulting RNA sequence and its final product, which is a protein in the case that this gene is used to synthesize a messenger RNA (mRNA) sequence

Step-by-step explanation:

During the transcription, a region of DNA named 'gene' is used as template to produce an RNA molecule, typically a primary transcript of mRNA (pre-mRNA). Subsequently, this pre-mRNA suffers a process named RNA processing in order to generate a mature mRNA which is finally used to create a protein by a process called translation. If a deletion occurs during transcription, it may change the open reading frame (ORF) of the resulting mRNA when the mutation occurs in an exon of the protein-coding gene (i.e., occurs a frameshift mutation), while this deletion may not have any effect if it is localized within the introns which are removed during RNA processing. A frameshift mutation will change the amino acids that are added to the nascent polypeptide chain during translation.