When we have a chemical reaction, the speed of the reaction will depend on different factors such as concentration, temperature, or pressure.
If we assume that the temperature and pressure remain constant, it will be the concentration that will determine the rate of reaction for a non-zero order reaction.
If the concentration of the reactants decreases, the reaction rate also decreases, therefore, if the reactants are depleted, the reaction rate decreases.
Answer: D. The rate of the reaction slows down.