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Why does trisomy and monosomy occur? And why are they so bad on the molecular level?

User Volume One
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Answer: Because the Monosomy (the lack of one member of a chromosome pair) and trisomy (a triplet instead of the normal chromosome pair) are typically the result of nondisjunction during meiosis. When this happens, one gamete shows monosomy, and the other shows trisomy of the same chromosome.In general, a monosomic for a particular chromosome is more severely abnormal than is the corresponding trisomic. trisomy 13, 18, 21, Triploidy and Turner syndrome: the 5T's.

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Why does trisomy and monosomy occur? And why are they so bad on the molecular level-example-1
User Damien
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Tanto en vegetales como en animales, las trisomías se pueden detectar mediante observación citológica de la división meiótica. Ya que hay tres copias de uno de los cromosomas, las configuraciones de apareamiento son normalmente irregulares.

User Wink Saville
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