A large family has a history of multiple aneuploid diseases such as Down Syndrome, trisomy-18 and Klinefelter Syndrome (XXY). The propensity to defects seems to be inherited, but the gene responsible is unknown.
What types of candidate genes would be most likely to lead to aneuploidy if they were mutated?
A. Genes that are part of the G1 checkpoint of mitosis.
B. Genes that encode proteins involved in chiasma formation.
C. Histone genes.
D. Genes that control DNA synthesis.