Final answer:
Enteric-coated iron results in lower iron absorption because it may bypass the area of the gastrointestinal tract where acidic pH aids in optimal iron release and absorption.
Step-by-step explanation:
The statement 'Enteric-coated iron results in lower iron absorption' is true. Enteric-coated medications are designed to pass through the stomach intact and dissolve in the more alkaline environment of the intestine. Given that iron absorption mainly occurs in the duodenum and the proximal jejunum, where the acidic pH favors the breakdown into free ferric ions or loosely bound organic iron the coating may prevent the iron from being released in an optimal area for absorption. Reduced substances like cysteine and ascorbic acid which are typically present in the stomach help to convert ferric iron into the more soluble ferrous form that is more readily absorbed.
Factors such as achlorhydria (absence of stomach acid) alkaline pH and certain dietary elements like phosphate phytic acid, and oxalic acid can decrease iron absorption by forming insoluble compounds with iron. In contrast, protein ingestion and alcohol can favor iron absorption. Understanding these interactions is key for optimizing iron supplementation effectiveness.