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Which one of the following compounds does not undergo a friedel-crafts reaction?

a. anisole
b. benzene
c. nitrobenzene
d. chlorobenzene
e. toluene

1 Answer

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Final answer:

Nitrobenzene does not undergo a Friedel-Crafts reaction due to the strong electron-withdrawing nature of the nitro group, which deactivates the benzene ring towards electrophilic aromatic substitution.

Step-by-step explanation:

The compound that does not undergo a Friedel-Crafts reaction among the ones listed is nitrobenzene. This is due to the fact that the nitro group (NO2) is a very strong electron-withdrawing group through resonance and inductive effects, which makes the benzene ring less reactive towards electrophilic aromatic substitution reactions such as the Friedel-Crafts reaction. The presence of the nitro group on the benzene ring deactivates the ring and hinders the formation of the carbocation intermediate necessary for the reaction to proceed.

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