Question

Which description best characterizes drug metabolism involving conjugation of a drug with glucoronate?

A.reduces the rate of biliary drug excretion
B.increases the rate of renal drug excretion
C.typically increases the pharmacologic activity of the drug
D.primarily occurs in the smooth endoplasmic reticulum
E.often induced or inhibited by other drugs

Answer 1

Drug metabolism involving conjugation of a drug with glucoronate typically increases the pharmacologic activity of the drug.

Step-by-step explanation:

The conjugation of a drug with glucuronate is a phase II metabolic reaction that typically increases the pharmacologic activity of the drug. Glucuronic acid, derived from uridine diphosphate glucuronic acid, is used to conjugate aromatic acids, phenols, bile pigments, and derivatives of steroid hormones before excretion. This conjugation reaction occurs in the liver and usually takes place in the smooth endoplasmic reticulum.