Final answer:
A short source-to-image distance with a large image receptor size will markedly increase the anode heel effect, leading to a variation in x-ray intensity across the x-ray field.
Step-by-step explanation:
Using a short Source-to-Image Distance (SID) with a large Image Receptor (IR) size is likely to increase the anode heel effect. The anode heel effect refers to the variation of x-ray intensity across the x-ray field, which is more pronounced at shorter distances and with larger IR sizes. As a result, the intensity of radiation on the anode side (heel) of the x-ray tube will be lower than on the cathode side, because the anode absorbs more x-rays due to its geometry and the attenuation of x-rays within the anode material itself.