Final answer:
It is true that before an e-script can be considered valid, both the prescriber's and pharmacist's computer systems must be certified to comply with DEA rules, ensuring a valid prescriber electronic signature and preventing prescription fraud.
Step-by-step explanation:
The assertion that before an e-script may be considered valid, both the prescriber's and the pharmacist's computer systems must be certified to comply with DEA rules is true. Assuring a valid prescriber electronic signature involves rigorous processes for identity proofing and authentication before electronic prescriptions for controlled substances (EPCS) can be issued or dispensed. The DEA's regulations explicitly require that the systems used by prescribers and pharmacies participating in EPCS must be independently audited and certified to meet specific criteria outlined by the DEA, or they must be certified by an approved third-party auditor to ensure that they meet the DEA's standards for security and integrity. This requirement is in place to prevent prescription fraud and drug diversion by using secure electronic means to manage prescriptions for controlled substances.