Question

Due to incompletely developed renal function in neonates and infants, which affects the elimination of amoxicillin, the dose is 30mg/kg/ day, divided and administered every 12 hours. A pharmacist receives a medication order for an infant weighing 15−lb, with a mild upper respiratory infection. A bottle of amoxicillin pediatric drops is prescribed which when reconstituted with the addition of 23 mL of water, a 30−mL suspension of amoxicillin, 50mg/mL, is prepared.

Calculate:
a) the volume occupied by the dry amoxicillin content?

Answer 1

The volume occupied by the dry amoxicillin content, when reconstituted to a 30mL suspension at 50mg/mL, is equivalent to 1.5g of dry amoxicillin.

Step-by-step explanation:

To calculate the volume occupied by the dry amoxicillin content, we need to use the information that the reconstituted amoxicillin suspension has a concentration of 50mg/mL and comes to a total volume of 30mL.

Therefore, the total amount of amoxicillin in the suspension is:
30mL × 50mg/mL = 1500mg

Since 1g = 1000mg, we can convert this to grams:
1500mg ÷ 1000 = 1.5g

Thus, the total mass of the dry amoxicillin before reconstitution is 1.5g.