Question

What is the duration of action of naloxone?

Answer 1

In one study, the duration of action was 45 minutes following IV administration of naloxone hydrochloride 0.4 mg/70 kg.

Answer 2

However, as the half-life of naloxone after IV administration is approximately 1 h and the duration of effect is 45–180 min, there is a risk of recurrence of respiratory depression or inadequate response following reversal with naloxone when treating the effects of long-acting, high-dose or potent synthetic opioids.

Step-by-step explanation: