Final answer:
The New England colonies were primarily settled for religious freedom, the Middle Colonies for both religious freedom and profit, and the Southern Colonies for profit, with some religious motives in Maryland.
Step-by-step explanation:
To understand the primary reasons for settlement in each Colonial region, we must look to the historical motivations of the settlers. For the New England colonies, such as Massachusetts, the primary reason was A. Religious freedom. This region was largely settled by Puritans seeking freedom to practice their religion without persecution.
The Middle Colonies, including areas such as New York and New Jersey, had strong commercial beginnings, coupled with a diversity of faiths and a push for religious tolerance. Therefore, the primary reason for their settlement was C. Both economic prospects and religious freedom. In the Southern Colonies, the significant motive was B. Profit, with the establishment of plantations and the search for wealth being predominant; however, elements of seeking religious freedom were also present in places like Maryland. Nonetheless, profit was the driving factor for settlement.