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Why is the 16s rrna so ideal as a molecular chronometer to study the microbiome?

a. it is highly conserved
b. it is easy to isolate in the lab we have studied it extensively
c. it accrues mutations very slowly over time
d. we can measure the differences through nucleotide comparisons

1 Answer

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Final answer:

The 16S rRNA is an ideal molecular chronometer due to its highly conserved nature, slow mutation rate, and our extensive research that enables accurate comparison of nucleotide sequences to study evolutionary relationships and history.

Step-by-step explanation:

The 16S rRNA is considered ideal as a molecular chronometer to study the microbiome for several reasons. First, it is highly conserved, which means that it has remained relatively unchanged throughout the evolution of various species. This conservation is helpful because it allows for the accurate comparison of nucleotide sequences between different organisms to establish evolutionary relationships. Additionally, because the 16S rRNA gene accrues mutations very slowly over time, it provides a reliable measure for studying evolutionary events over long periods. Moreover, due to extensive research, we have a comprehensive understanding of this molecule, facilitating its use in lab studies. For instance, analyzing ancient 16S rRNA sequences allows us to match them with modern strains, as seen in the comparison between 14th-century skeletal remains and the modern Yersinia pestis bacterium.

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