Final answer:
Basophils indeed mediate allergic reactions by releasing histamines that contribute to inflammation and allergy symptoms. They are part of the immune system's response to allergens and are involved in both mild and severe allergic reactions.
Step-by-step explanation:
The statement that basophils mediate allergic reactions is True. Basophils play a significant role in the body's defense mechanisms, primarily in the inflammatory response and the development of allergies. They release histamines and heparin upon activation. Specifically, histamines contribute to inflammation and allergy symptoms. Basophils, along with mast cells, are involved in the body's response to allergens.
When an individual is exposed to an allergen, IgE antibodies are synthesized which sensitize mast cells. On subsequent exposure, these antibodies cause mast cells to release histamine and other inflammatory mediators, which then recruit eosinophils. Eosinophils release factors that enhance the inflammatory response and mast cell secretions, leading to the various symptoms associated with allergic reactions, ranging from mild to potentially life-threatening anaphylactic shock.