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The error frequency of protein synthesis is approximately:

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The error frequency of protein synthesis is quite low, with sophisticated cellular mechanisms ensuring high fidelity during the rapid translation process. A 200-amino acid protein can be synthesized in approximately 10 seconds, and errors are rare but can cause significant consequences.

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Error Frequency in Protein Synthesis

The error frequency of protein synthesis in cells is a crucial aspect of molecular biology that ensures the correct formation of proteins. The process of translation, or protein synthesis, is remarkably accurate, considering that an E. coli translation apparatus can add amino acids at a rate of 0.05 seconds per amino acid. This means a 200-amino acid protein can be synthesized in about 10 seconds. The efficiency and fidelity of the protein synthesis process are further underscored by the various quality control mechanisms in place within the cell, such as the presence of the DNA ligase enzyme that mitigates replication errors and the highly conserved nature of the genetic code.

While the synthesis of proteins is the most energy-consuming metabolic process, it's also critical since proteins comprise the majority of a cell's mass aside from water and perform nearly every cellular function. Errors during this process can lead to significant consequences, including hereditary and age-related diseases. Studies such as those by Haig and Hurst (1991) have quantified the error minimization in the genetic code, and while exact figures on error rates can vary depending on the organisms and conditions, the occurrence is generally infrequent, underscoring the precision of the genetic machinery.

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