Question

Genetic disorders demonstrating genomic imprinting—Prader-Willi syndrome and Angelman syndrome—result from the deletion of a(n) ________ on chromosome 15.

A. imprintosome
B. centromere
C. enhancer
D. nucleosome.

Answer 1

Genetic disorders demonstrating genomic imprinting—Prader-Willi syndrome and Angelman syndrome—result from the deletion of a(n) imprintosome on chromosome 15.

Step-by-step explanation:

Genetic disorders demonstrating genomic imprinting—Prader-Willi syndrome and Angelman syndrome—result from the deletion of a(n) imprintosome on chromosome 15. The imprintosome is a group of genes that regulate gene expression through DNA methylation and histone modification. In Prader-Willi syndrome, the imprintosome is deleted on the chromosome inherited from the father, while in Angelman syndrome, it is deleted on the chromosome inherited from the mother. This deletion leads to abnormal gene expression and the characteristic symptoms of each syndrome.