Final answer:
Stephen Hawking said the quote, which emphasizes the gaps in our knowledge of the natural world, in his book A Brief History of Time.
Step-by-step explanation:
The quote, "there is nothing unnatural in the universe, only large gaps in our knowledge of how nature herself works," is from physicist Stephen Hawking. Hawking made this statement in his book, A Brief History of Time, which explores the mysteries of the universe and our understanding of it.