Final answer:
The natural disaster that destroyed Malala's region of Pakistan and killed thousands was a flood.
Step-by-step explanation:
The natural disaster that occurred in Malala's region of Pakistan, causing destruction and killing thousands, was a flood. Pakistan is prone to flooding due to its geography and climate. The country is located on a tectonic plate boundary and experiences shifting tectonic plates, which can cause earthquakes. Additionally, Pakistan's low-lying agricultural lands are vulnerable to flooding, especially during monsoon seasons.