Final answer:
Lorenzo Ghiberti used a rectangular frame to encase the scene of Isaac in his Sacrifice of Isaac. Inside the frame, he depicted the scene of Isaac being sacrificed by his father, Abraham.
Step-by-step explanation:
In Lorenzo Ghiberti's Sacrifice of Isaac, he used a geometric combination to encase the scene. The geometric combination he used was a rectangle. Ghiberti created a rectangular frame to hold the scene of Isaac. Inside this frame, he depicted the scene of Isaac being sacrificed by his father, Abraham.