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The three-dimensional shape of a protein is determined by the primary, secondary, tertiary, and in many cases, the quaternary structure of the protein. The following sentence is taken from scientific articles on protein structure. Choose the level of protein structure that applies best to the sentence.

Peptide bonds form between the monomers.

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Final answer:

The sentence in question refers to the primary structure of proteins, which is the sequence of amino acids linked by peptide bonds. This level is foundational in determining the protein's final three-dimensional shape and functionality, including subsequent secondary, tertiary, and quaternary structures.

Step-by-step explanation:

Understanding Protein Structure

The sentence 'Peptide bonds form between the monomers' refers to the primary structure of proteins. The primary structure consists of the linear sequence of amino acids in a polypeptide chain, which is linked by peptide bonds. It is the most basic level of protein structure and contains the unique sequence of amino acids that will ultimately determine the final three-dimensional shape of the protein through a series of folding patterns at higher structural levels.


The secondary structure gives rise to alpha-helices and beta-pleated sheets, while the tertiary structure refers to the overall three-dimensional shape of a single polypeptide chain. In the case where more than one polypeptide chain comes together, a quaternary structure is formed. Each of these structures relies on various interactions, including hydrogen bonds, ionic bonds, hydrophobic interactions, and in some cases, disulfide bridges.

Proteins are classified as either fibrous or globular, based on their solubility and structural properties. Understanding these structures is critical, as the shape of a protein is intimately connected with its function, such as an enzyme's ability to bind to a specific substrate. Disruption of these structures through denaturation can lead to a loss of function, demonstrating the importance of proper protein folding.

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