Question

Prader-Willi syndrome is associated with the imprinting of a gene encoding a splicing factor called blank.

a) UBE3A
b) NDN
c) SNORNA
d) SNRPN

Answer 1

Prader-Willi syndrome is associated with the imprinting of a gene that encodes a splicing factor known as SNRPN, which is found on chromosome 15.

Step-by-step explanation:

Prader-Willi syndrome (PWS) is a genetic disorder associated with the loss of gene function on chromosome 15. One of the genes involved in this syndrome encodes a splicing factor, and the correct answer to the question is d) SNRPN. This gene is subject to parental imprinting, where only the paternal allele is usually active, leading to the syndrome when this region is missing or not functioning properly. PWS is characterized by symptoms such as constant hunger, which often leads to severe obesity, as well as cognitive deficits and emotional problems.

Answer 2

Prader-Willi syndrome is associated with the loss of function on chromosome 15, specifically with the imprinting of the SNRPN gene, which encodes for a splicing factor.

Step-by-step explanation:

Prader-Willi syndrome is associated with the imprinting of a gene encoding a splicing factor called SNRPN. This syndrome is caused by the loss of function of specific genes on chromosome 15.

Symptoms of Prader-Willi syndrome include constant hunger and severe obesity in childhood. It is a genetic disorder that results in persistent feelings of intense hunger and reduced rates of metabolism.

Prader-Willi syndrome (PWS) is a complex genetic disorder that results from the loss of function of genes on chromosome 15. Among the symptoms, the syndrome is characterized by constant hunger and the risk of developing severe obesity during childhood.

The gene associated with the imprinting defect in Prader-Willi syndrome that encodes a splicing factor is SNRPN (small nuclear ribonucleoprotein polypeptide N). The correct option is d) SNRPN. This loss of function typically occurs due to imprinting errors rather than direct inheritance.