Question

On a 12-hour dosing cycle, Toxicity is more likely if therapy is

Answer 1

Toxicity is more likely in a 12-hour dosing cycle if the dosage and intervals are not carefully adjusted for individual patient factors, particularly in those with impaired liver or kidney function.

Step-by-step explanation:

On a 12-hour dosing cycle, toxicity is more likely if therapy is not appropriately tailored to the individual's physiology and metabolism. Optimizing the dosage and route of administration is crucial for minimizing the risk of side effects while still achieving a clinical cure. In certain patients, such as those with liver or kidney dysfunction, there is reduced drug metabolism or clearance, which can result in increased drug levels and elevate the risk of toxicity. This emphasizes the importance of considering individual patient factors, including organ function and potentially body mass for all age groups, when determining appropriate dosage intervals and amounts.