Final answer:
Ischemia, or reduced blood flow to a tissue region, can lead to tissue death through hypoxia, or a decreased supply of oxygen to the tissues.
Step-by-step explanation:
Ischemia, which is reduced blood flow to a tissue region, can lead to tissue death via hypoxia, which is decreased oxygen supply to the tissues. When blood vessels narrow and limit the blood flow, the affected tissue region can experience ischemia, causing a decrease in oxygen supply. If cardiac muscle or brain tissue are affected by hypoxia, it can result in cell death and severe impairment of brain or heart function.