Final answer:
The symbol that replaces the box to make the statement true is > (greater than).
Step-by-step explanation:
In the given expression, the symbol that replaces the box to make the statement true is > (greater than).
To determine this, we evaluate both sides of the expression starting from the innermost parentheses, following the order of operations (PEMDAS/BODMAS).
12:4+13 ? 2+22:2 = 12:4+13 ? 2+11 = 3+13 ? 2+11 = 16 ? 2+11 = 8+11 = 19.
Since 19 is greater than 2+11, the correct symbol to replace the box is > (greater than).