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Which enzyme is activated by both GPCRs and RTKs?

A. Phospholipase C
B. Adenylyl cyclase
C. MAP kinase
D. Protein kinase A
E. Guanylyl cyclase

1 Answer

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Final answer:

The enzyme activated by both GPCRs and RTKs is Phospholipase C (option A), which is involved in the cell signaling cascade leading to various cellular responses.

Step-by-step explanation:

The enzyme activated by both G Protein-Coupled Receptors (GPCRs) and Receptor Tyrosine Kinases (RTKs) is Phospholipase C. GPCRs activate Phospholipase C through a G-protein-mediated pathway, wherein an effector signal molecule binds to a receptor, activating the integral membrane Phospholipase C enzyme.



This enzyme catalyzes the formation of cytosolic inositol triphosphate (IP3) and membrane-bound diacylglycerol (DAG), which play a role in the cell signaling cascade. RTKs also lead to the activation of Phospholipase C through different mechanisms involving phosphorylation and recruitment of adaptor proteins. In contrast, adenylyl cyclase is activated by GPCRs but is not a point of convergence for RTK signaling. Therefore, the correct answer is A. Phospholipase C.

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