Final answer:
Glutamate is taken up from the synapse through reuptake by excitatory amino acid transporters (EAATs) located on the presynaptic neuron or neighboring glial cells. Glutamate is then converted to glutamine and transported back to the neuron.
Step-by-step explanation:
Glutamate, the main excitatory neurotransmitter in the central nervous system (CNS), is taken up from the synapse through reuptake by excitatory amino acid transporters (EAATs). These transporters are located on the presynaptic neuron or neighboring glial cells and transport glutamate back into the cell. Glutamate is then converted to glutamine by glutamine synthase in glial cells and transported back to the neuron.