Final answer:
Nuclear changes in necrosis include DNA scattering throughout the cytoplasm after the nuclear envelope breaks down. The plasma membrane becomes compromised, losing its selective permeability and allowing free entry of external substances. Cellular lysis is facilitated by lysosomes releasing enzymes, creating multiple rupture points.
Step-by-step explanation:
Necrosis is a form of cell death that occurs when cells are damaged by external factors. During necrosis, there are significant nuclear changes that occur within a cell. The cell's DNA does not remain intact within the nucleus but instead can become scattered throughout the cytoplasm following the breakdown of the nuclear envelope. In a necrotic cell, the cell membrane loses its integrity, allowing external substances to enter the cell freely.
This lack of selective permeability causes the cellular contents to leak out, potentially leading to inflammation in the surrounding tissues. The presence of lysosomes can lead to autolysis, causing multiple rupture points in the plasma membrane as these organelles release their hydrolytic enzymes, contributing to cell lysis.