Final answer:
Two characteristics, abnormal accumulation of prion proteins and presence of 14-3-3 protein in CSF, predict clinical and pathological features in sCJD.
Step-by-step explanation:
Creutzfeldt-Jakob disease (CJD) is a transmissible spongiform encephalopathy (TSE) caused by an infectious variant of a normal cellular protein called PrP (prion protein). There are two characteristics that predict clinical and pathological features in sporadic CJD (sCJD). The first characteristic is the abnormal accumulation of prion proteins, which leads to the formation of sponge-like lesions in the brain tissue. The second characteristic is the presence of a specific protein called 14-3-3 protein in the cerebrospinal fluid (CSF). These two characteristics can be used to diagnose sCJD and differentiate it from other neurodegenerative diseases.