Question

Why is clopidogrel preferred over other drugs for long-term dual therapy with aspirin?

Option 1: Faster onset of action.

Option 2: Lower risk of bleeding.

Option 3: Greater platelet inhibition.

Option 4: Reduced gastrointestinal side effects.

Answer 1

Clopidogrel is preferred for long-term combination with aspirin due to its lower risk of bleeding, which makes it safer for long-term use, especially in reducing cardiovascular events in high-risk patients. (Option 2).

Step-by-step explanation:

Clopidogrel is often preferred over other drugs for long-term dual therapy with aspirin due to its lower risk of bleeding (Option 2). This dual anti-platelet therapy, consisting of clopidogrel plus aspirin, is more effective at reducing cardiovascular events than aspirin alone, especially in patients with STEMI or those who have had a stent placed. Aspirin is known for its anticoagulant effects, as it inhibits the aggregation of platelets, but it can increase the risk of ulcers and other gastrointestinal side effects when used long-term. Therefore, when combined with clopidogrel, which has a safety profile that includes a lower risk of bleeding compared to some other antiplatelet agents, it offers an effective approach to managing the risk of cardiovascular events while mitigating some of the gastrointestinal risks associated with aspirin therapy.