Question

Compare and contrast the clinical pharmacology of ticagrelor and clopidogrel?

Option 1:
A. Clopidogrel is reversible, while ticagrelor is irreversible.

Option 2:
B. Ticagrelor has a faster onset of action than clopidogrel.

Option 3:
C. Clopidogrel is associated with fewer drug interactions.

Option 4:
D. Ticagrelor requires renal activation, unlike clopidogrel.

Answer 1

Ticagrelor and clopidogrel are anti-platelet drugs with important differences in their clinical pharmacology. Clopidogrel is reversible, while ticagrelor is irreversible. Ticagrelor has a faster onset of action than clopidogrel. Clopidogrel is associated with more drug interactions compared to ticagrelor.

Step-by-step explanation:

Ticagrelor and clopidogrel are both anti-platelet drugs used to prevent cardiovascular events. While both drugs are effective, they have some important differences in terms of their clinical pharmacology.

1. Option 1: Clopidogrel is a prodrug that requires activation in the liver, while ticagrelor is an active drug. Therefore, the effect of clopidogrel is reversible, while ticagrelor is irreversible.
2. Option 2: Ticagrelor has a quicker onset of action compared to clopidogrel. This makes ticagrelor a more suitable choice in acute situations requiring rapid platelet inhibition.
3. Option 3: Clopidogrel is associated with a higher risk of drug interactions compared to ticagrelor. This is because clopidogrel is metabolized by a specific hepatic enzyme pathway which is susceptible to drug interactions.