Final answer:
A toothbrush should be replaced when the bristles begin to splay outward and show signs of wear to maintain oral health.
Step-by-step explanation:
The question "A toothbrush should be replaced when the bristles begin to splay outward and show signs of wear" is related to personal dental hygiene. The correct answer is D. when the bristles begin to splay outward and show signs of wear. It is generally recommended to replace your toothbrush every three to four months, but if the bristles are worn out earlier, it is important to change it right away to maintain proper oral health. While some may suggest replacing a toothbrush after traveling or when a new one is obtained from a dental office, these are not standard guidelines followed by dental professionals.