Final answer:
Individuals with Down syndrome have an increased risk of both leukemia and solid tumors.
Step-by-step explanation:
Individuals with Down syndrome have an increased risk of both leukemia and solid tumors. Down syndrome (47 XY +21) is caused by having three copies of chromosome 21, known as trisomy 21, which can lead to various health issues, including a higher susceptibility to cancer. While they have an increased risk of leukemia, they also have an increased risk of developing solid tumors.