Final answer:
A higher un-ionized fraction and a higher partition coefficient indicate a substance is more lipophilic, meaning it is more soluble in nonpolar or lipid-soluble solvents. Lipophilic substances can easily pass through plasma membranes compared to polar substances.
Step-by-step explanation:
Solubility refers to the ability of a substance to dissolve in a particular solvent. A higher un-ionized fraction and a higher partition coefficient indicate a substance is more lipophilic, meaning it is more soluble in nonpolar or lipid-soluble solvents. Lipophilic substances can easily pass through plasma membranes compared to polar substances.
In the context of lipophilicity, a higher un-ionized fraction and a higher partition coefficient indicate that a substance is more lipophilic. Lipophilic substances are more soluble in nonpolar or lipid-soluble solvents compared to polar solvents. This is because nonpolar or lipid-soluble substances pass through plasma membranes more easily than polar substances, allowing for a faster rate of diffusion.