Final answer:
The anterior talofibular ligament is most commonly injured during supination of the ankle, and it is often affected first in an inversion ankle sprain.
Step-by-step explanation:
The ligament that is more commonly injured during supination of the ankle is the anterior talofibular ligament. The ankle joint is prone to various injuries, with the most frequent being an inversion ankle sprain.
During an inversion sprain of the ankle, which is an excessive inversion of the foot, the anterior talofibular ligament is the first to get injured due to its location on the lateral side of the ankle. It is followed by the calcaneofibular ligament, with both ligaments serving to resist excessive inversion movements. In severe cases, this type of injury can also lead to a fracture of the distal fibula.