To integrate Microsoft Defender for Office 365 with Microsoft Defender for Endpoint in a Microsoft 365 Enterprise E5 subscription, configure the settings in the Microsoft 365 security center under the Endpoints section.
The integration of Microsoft Defender for Office 365 and Microsoft Defender for Endpoint is a key aspect for enhancing security across email and collaboration tools as well as endpoint devices. To configure this integration within a Microsoft 365 Enterprise E5 subscription, you need to do this within the Microsoft 365 security center. Specifically, you navigate to the Endpoints section under the settings panel, where you can set up the cooperative policies and rules to facilitate the sharing of security signals and alerts between Defender for Office 365 and Defender for Endpoint.