Question

Aminoglycosides: Who can sterilize my bowel?
______-mycin & ______-mycin

Answer 1

Aminoglycosides such as Neomycin and Kanamycin bind to bacterial ribosomal subunits, impairing proofreading and leading to the production of faulty proteins, which can be used to sterilize the bowel pre-surgically or in immunocompromised patients.

Step-by-step explanation:

Aminoglycosides are antibacterial drugs that play a critical role in treating infections by binding to the 30S subunit of bacterial ribosomes. This binding impairs the ribosomal complex's proofreading capability, leading to mismatches in codons and anticodons and thus, the production of faulty proteins that disrupt the bacterial cytoplasmic membrane. Two common aminoglycosides that can be used for bowel sterilization are Neomycin-mycin and Kanamycin-mycin. Both drugs have demonstrated efficacy in reducing the bacterial load in the intestines prior to surgical procedures, and they can be used when there's a need to minimize infection risks in immunocompromised patients.

Answer 2

Aminoglycosides like neomycin and kanamycin bind to the 30S subunit of bacterial ribosomes, sterilizing the bowel by killing bacteria, with potential nephrotoxic, neurotoxic, and ototoxic side effects.

Step-by-step explanation:

Aminoglycosides are potent antibacterials known for their ability to bind to the 30S subunit of bacterial ribosomes, resulting in the production of abnormal proteins that disrupt bacterial cell membranes and lead to cell death. The two aminoglycosides that can sterilize the bowel are neomycin-mycin and kanamycin-mycin.

These antibiotics are used prior to surgical procedures to minimize infection risks from bowel microbes, particularly in immunocompromised patients. It's important to note that while effective, aminoglycosides have potential side effects including nephrotoxicity, neurotoxicity, and ototoxicity.