Final answer:
The two vitamins that participate in the TCA cycle are Thiamine (Vitamin B1) and Riboflavin (Vitamin B2), both of which are essential cofactors for enzymes that facilitate key reactions in the cycle.
Step-by-step explanation:
The TCA cycle, also known as the Krebs cycle or citric acid cycle, is a central metabolic pathway that plays a vital role in generating energy by oxidizing acetyl-CoA to produce CO₂, NADH, FADH₂, and ATP. Among the various vitamins that facilitate this process, the two main vitamins participating in the TCA cycle are Thiamine (Vitamin B₁) and Riboflavin (Vitamin B₂).
Thiamine, in the form of thiamine pyrophosphate (TPP), is a key cofactor for the enzyme pyruvate dehydrogenase, which is vital for the decarboxylation of pyruvate to acetyl-CoA, linking glycolysis to the TCA cycle. Meanwhile, Riboflavin, as part of the coenzymes FAD and FMN, is crucial in the oxidation-reduction reactions within the cycle, especially in the conversion of succinate to fumarate.