Final answer:
The sister should undergo screening colonoscopy right away and repeat every 3-5 years if normal.
Step-by-step explanation:
The sister should be advised to undergo screening colonoscopy right away and repeat every 3-5 years if normal. Colonoscopy is considered the gold standard for the diagnosis of colorectal cancer, as it allows for visualization of the entire colon and the removal of any precancerous polyps.